Bariatric surgery, bone loss, obesity and possible mechanisms

Vitamin D Metabolism and Bone Loss After Bariatric Surgery

Obesity surgery is a highly effective treatment for morbidly obese patients. Despite effective weight reduction, the impact of bariatric surgery on bone is a major concern. Mechanisms of the deleterious effect include calcium and vitamin D malabsorption with secondary hyperparathyroidism (SHPT), deficiency in other nutrients and alterations in gut-derived hormones. Sleeve gastrectomy (SG) and R...

The obesity puzzle: focus on bone turnover after bariatric surgery.

Mechanisms responsible for excess weight loss after bariatric surgery.

Obesity has increased alarmingly in the United States and is increasing in many countries of the world. Because obesity is an important risk factor for type 2 diabetes and other chronic diseases, it is important to develop approaches to counter the rapid increase in adiposity. One approach is bariatric surgery, the most successful clinical intervention known for treating obesity. Surgery can re...

Bariatric Surgery in Hypothalamic Obesity

Craniopharyngiomas (CP) are epithelial neoplasms generally found in the area of the pituitary and hypothalamus. Despite benign histology, these tumors and/or their treatment often result in significant, debilitating disorders of endocrine, neurological, behavioral, and metabolic systems. Severe obesity is observed in a high percentage of patients with CP resulting in significant comorbidities a...

Bariatric surgery for morbid obesity.

n engl j med 356;21 www.nejm.org may 24, 2007 2176 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are prese...